[ harmful effect of quinolone [pefloxacine] on immature cartilage in juvenile rat]

The aim of our study was definition of the exact mechanism by which quinolone harm the immature cartilage causing arthropathy, and upon these results we can determine the suitable treatment for this damage. This effect was studied in four groups of juvenile wistar rats as following:1- normal group.2- the group of pefloxacine with a dose 15 mg/kg per day for one month. 3- the group of pefloxacine 15mg/kg per day for one month with addition of the magnesium ions with compensate amount 84mg/kg per art. 4- the group of pefloxacine 15mg/kg per day for one month with addition of vitamin E with compensate amount75mg/kg per rat. The drugs were administered by incubation tube for one months, and at the end of the experiment blood samples were took from animals hearts preparing for measuring malondialdehide, then animals were scarified and the maximum extension angle of the knee joints was measured, then we put the joints in the formol for the histological study. Pefloxacine increased the values of maximum extension angle significantly in compare to the normal group and the control group, with significant improvement in the group of magnesium ions and the group of vitamin E but non of each group could return the cartilage to the normal condition. The results of malondiadehyde assay inssure the effect of free radicals in this arthropathy. Histological study: pefloxacine damage significantly the cartilage and the damage was decreased in the addition of magnesium or vitamin E. There is a lot of factors participate in causing the arthropathy which induced by taking quinolone and this pathology don't confine on the participate of magnesium ions or oxidative stress.

Teratogenic effects of ciprofloxacin and pefloxacin in pregnant rats

The adverse effects of ciprofloxacin and pefloxacin on rat fetuses following oral administration to the pregnant rats were studied. Ciprofloxacin and pefloxacin were given daily to pregnant rats at two [therapeutic and double therapeutic] dosage levels during the period of organogenesis [from the 6[th] to the 15[th] of gestation]. Oral administration of ciprofloxacin at 4.5 and 9 mg/100 g.b.wt. to pregnant rats induced fetal resorption, death and growth retardation. Visceral examination of live fetuses showed microcephaly, hypoplasia of the heart and lungs and dilatation of renal pelvis. Skeletal examination reveated incomplete ossification of skull bones and absence of some coccygeal vertebrae. Pefloxacin at 7.2 6 mg/100 g. b. wt. decrease the number of live fetuses and caused microcephaly, hypoplasia of the heart and lungs, dilatation of the renal pelvis. It also induced incomplete ossification of skull bones and absence of sternbrae and phalanges of forelimbs. A great attention should be considered during the clinical use of ciprofloxacin and pefloxacin in pregnant women and animals to avoid their teratogenic effects

Quinolone induced arthropathy in adolescents and adults

To ascertain the incidence, clinical pattern and outcome of arthropathy in adolescents and adults induced by different quinolones. Cases of enteric fever treated with different quinolones having no previous history of joint disorders who developed arthropathy and improved well with conservative treatment were labelled as quinolone induced arthropathy. In-patients of Rajshahi and Khulna Medical College Hospitals and private clinics of the authors. Four hundred and three cases of enteric fever were treated with various quinolones during the period January 1995 to June 1999. Main outcome measures: Clinical characteristics, incidence, relation with quinolones used and outcome of quinolone induced arthropathy. The age of the 403 [males 260 and females 143] patient ranged from 13-60 years. They were treated with either ciprofloxacin, pefloxacin or ofloxacin. Out of them 31 [7.7%] patients developed arthropathy. It was highest with pefloxacin [12.5%]. The arthropathy was maximum [11.8%] in the age group of 11-20 years. Patterns of arthropathy were oligoarthropathy [23], polyarthropathy [7] and monoarthropathy [1]. Although quinolones use is not advocated in children for development of arthropathy, it also occurs in adolescents and adults in considerable number of cases. It improves well with conservative treatment without residual effect